CRYO-ELECTRON MICROSCOPY (CRYO-EM)

CEMAS is at the forefront in the convergence of physical and life sciences. Our multidisciplinary approach drives synergy and amplifies characterization capabilities to challenge "what is possible" in electron microscopy. Our comprehensive cryo-electron microscopy (cryo-EM) program advances this effort.

Located in a custom-designed facility, all cryo-EM instruments at CEMAS meet or exceed manufacturer performance specifications. CEMAS recently installed a Thermo Scientific Glacios Cryo-TEM with a Falcon III direct electron detector and a Ceta-D camera for MicroED analysis. In addition, CEMAS has a Thermo Scientific Krios G3i Cryo-TEM equipped with a Bioquantum imaging filter and a K3 direct electron detector, imaging phase plates, STEM/TEM tomography, and an image spherical aberration corrector.

CEMAS can assist users in all aspects of the cryo-EM workflow, including initial negative stain analysis, cryogenic sample preparation, grid screening, high-resolution data collection, and preliminary data analysis.

To get started, apply to become a CEMAS user. View the Policies and Procedures for using the Cryo-Electron Microscopy facilities at CEMAS.

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Researchers at Ohio State have organized an informal Cryo-EM Interest Group that meets 1-2 times per month. Meetings consist of a highlight talk lasting approximately 30 minutes, followed by a discussion about data analysis, sample preparation, and other cryo-EM focused topics. The group also welcomes outside speakers to talk about their research.

Are you interested in joining? Connect with CEMAS Cryo-EM Researcher Yoshie Narui at narui.2@osu.edu.

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